Beneficial effects of tolvaptan on atrial remodeling induced by chronic intermittent hypoxia in rats.
Kai ZhangZuowang MaWeiding WangRuimeng LiuYue ZhangMeng YuanGuangping LiPublished in: Cardiovascular therapeutics (2018)
CIH-induced significant atrial remodeling in our rat model, which was attenuated by tolvaptan. These changes may be explained due to alterations in miR-21/Spry1/ERK/MMP-9, miR-21/PTEN/PI3K/AKT, and NF-κB pathways by tolvaptan.
Keyphrases
- pi k akt
- cell proliferation
- signaling pathway
- acute heart failure
- polycystic kidney disease
- cell cycle arrest
- long non coding rna
- atrial fibrillation
- left atrial
- long noncoding rna
- high glucose
- endothelial cells
- heart failure
- diabetic rats
- catheter ablation
- high intensity
- oxidative stress
- cell migration
- immune response
- mitral valve