Inhibition of Intimal Thickening By PRH (Proline-Rich Homeodomain) in Mice.

Lien M ReolizoHelen WilliamsKerry WadeyAleksandra FrankowZe LiKevin GastonPadma-Sheela JayaramanJason L Johnson Sarah Jane George

Published in: Arteriosclerosis, thrombosis, and vascular biology (2023)

We observed PRH S163C:S177C attenuated VSMC proliferation, and migration and enhanced VSMC differentiation at least in part via STAT-1 and HDAC-9 signaling while promoting endothelial repair and anti-inflammatory properties. These findings highlight the potential for PRH S163C:S177C to preserve endothelial function whilst suppressing intimal thickening, and reducing late vein graft failure.

Keyphrases

anti inflammatory
transcription factor
signaling pathway
endothelial cells
cell proliferation
high fat diet induced
type diabetes
metabolic syndrome
skeletal muscle
wild type