Rapid Access to Oxa-Bridged Bicyclic Skeletons through Gold-Catalyzed Tandem Rearrangement Reaction.

A gold (I)-catalyzed reaction of enyne-ethers to rapidly construct oxa-bridged compounds via a tandem 1,2-acyloxy migration/intramolecular oxonium formation/1,2-rearrangement process was reported. The reaction was shown to be robust with a wide range of substitution patterns tolerated to provide the corresponding oxygen-containing bridged products in good to excellent yields.