T Cell-Derived IL-17A Induces Vascular Dysfunction via Perivascular Fibrosis Formation and Dysregulation of ·NO/cGMP Signaling.

Rebecca SchülerPanagiotis EfentakisJohannes WildJérémy LagrangeVenkata GarlapatiMichael MolitorSabine KossmannMatthias OelzePaul StammHuige LiKatrin SchäferThomas MünzelAndreas DaiberAri WaismanPhilip Wenzel Susanne Helena Karbach

Published in: Oxidative medicine and cellular longevity (2019)

Our data demonstrate that T cell-derived IL-17A elicits vascular dysfunction by mediating proliferation of fibroblasts and subsequent vascular fibrosis associated with PYK2 upregulation.

Keyphrases

oxidative stress
signaling pathway
cell proliferation
electronic health record
machine learning