T-regulatory cells exhibit a biphasic response to prolonged endurance exercise in humans.
Tom CliffordMatthew J WoodPhilip StocksGlyn HowatsonEmma J StevensonCatharien M U HilkensPublished in: European journal of applied physiology (2017)
These results suggest that Tregs do not play a major role in immune suppression in the early hours of recovery from a marathon. However, terminally differentiated HLA-DR+ Tregs are mobilized the following day, which could represent a compensatory attempt by the host to restore immune homeostasis and limit excessive cell damage.