Dupilumab but not cyclosporine treatment shifts the microbiome towards a healthy skin flora in patients with moderate to severe atopic dermatitis.
Jan HartmannLucas Moitinho-SilvaNicole SanderInken HarderRobert HäslerElke RodriguezEva HaufeAndreas KleinheinzSusanne AbrahamAnnice HeratizadehElke WeisshaarKnut SchäkelChristiane HandrickMatthias AugustinAndreas WollenbergPetra Staubach-RenzKonstantin ErtnerMichael SticherlingBeate SchwarzSven QuistFranca WiemersFlorian SchenckJulia WildbergerLukas TittmannWolfgang LiebJochen SchmittThomas WerfelStephan Weidingernull nullPublished in: Allergy (2023)
Systemic treatment with dupilumab but not cyclosporine tends to restore a healthy skin microbiome largely independent of the clinical response indicating potential effects of IL-4RA blockade on the microbiome.