Vasostatin-2 associates with coronary collateral vessel formation in diabetic patients and promotes angiogenesis via angiotensin-converting enzyme 2.

Xiao Lu BaoYang DaiLin LuXiao Qun WangFeng Hua DingWei Feng ShenYing ShenRaffaele De Caterina

Published in: European heart journal (2023)

Lower serum levels of vasostatin-2 are associated with poor CCV in diabetic CTO patients compared with patients with good CCV. Vasostatin-2 significantly promotes angiogenesis in diabetic mice with hindlimb or myocardial ischemia. Such effects are mediated by ACE2.

Keyphrases

angiotensin converting enzyme
angiotensin ii
end stage renal disease
endothelial cells
ejection fraction
coronary artery disease
vascular endothelial growth factor
type diabetes
coronary artery
peritoneal dialysis
left ventricular
prognostic factors
aortic stenosis