Evidence for a pre-malignant cell line in a skin biopsy from a patient with Nijmegen breakage syndrome.

Raneem HabibHeidemarie NeitzelAurelie ErnstJohn K L WongBozenna Goryluk-KozakiewiczAntje GerlachIlja DemuthKarl SperlingKrystyna Chrzanowska

Published in: Molecular cytogenetics (2018)

The aberrant cells had a significant selective advantage in vitro. It is therefore tempting to speculate that this highly unbalanced translocation could be a primary driver of cancer cell growth.

Keyphrases

induced apoptosis
case report
papillary thyroid
cell cycle arrest
squamous cell
soft tissue
ultrasound guided
oxidative stress
endoplasmic reticulum stress
squamous cell carcinoma
cell death
childhood cancer
young adults
pi k akt