Anatase and Rutile TiO2 Nanoparticles Lead Effective Bone Damage in Young Rat Model via the IGF-1 Signaling Pathway.

Wenshu ChengXinyue XuYuanyuan LangZugen ChengMohammad RizwanXiaomin TangLixin XieYanling LiuHengyi XuYang Liu

Published in: International journal of nanomedicine (2021)

This study demonstrated that TiO2 NPs can damage bones via the IGF-1/OPG/RANKL/CTSK pathway in young rats. Furthermore, rutile TiO2 NPs damaged the bones more seriously than anatase TiO2 NPs.

Keyphrases

visible light
quantum dots
pi k akt
signaling pathway
oxidative stress
middle aged
binding protein
oxide nanoparticles
bone loss
epithelial mesenchymal transition
postmenopausal women