Targeting Wnt-ß-Catenin-FOSL Signaling Ameliorates Right Ventricular Remodeling.
Sreenath Reddy NayakantiAleksandra FriedrichPoonam SarodeLeili JafariGiovanni MaroliMario BoehmAlice BourgeoisYann GrobsFatemeh KhassafiCarsten KuenneStefan GuentherSwati DabralJochen WilhelmAstrid WeissAstrid WietelmannBaktybek KojonazarovWiebke JanssenMario LoosoFrances S de ManSteeve ProvencherKhodr TelloHorst-Walter BirkSebastien BonnetSoni Savai PullamsettiRalph T SchermulySoni Savai PullamsettPublished in: Circulation research (2023)
Wnt- β-Catenin-FOSL signaling is centrally involved in the hypertrophic RV response to increased afterload, offering novel targets for therapeutic interference with RV failure in pulmonary hypertension.