Genetic Polymorphisms of XPC, XPD, XPG Genes and their Association with Radiotherapy Induced Toxicity among Head and Neck Cancer Patients: A Hospital Based Study from Maharashtra.

Anand K GudurShivani R KaleRashmi A GudurSuresh J BhosaleKailas D Datkhile

Published in: Asian Pacific journal of cancer prevention : APJCP (2024)

The results obtained in this study concluded that the SNPs rs2228001of XPC, rs238406, rs13181 SNPs of XPD and rs17655 SNP of XPG are not associated with normal tissue toxicity in HNC patients treated with radiotherapy. Radiotherapy with high radiation dose was significantly associated with oral mucositis in response to radiotherapy.

Keyphrases

early stage
radiation induced
genome wide
locally advanced
radiation therapy
oxidative stress
squamous cell carcinoma
rectal cancer
emergency department
gene expression
diabetic rats
endothelial cells
genome wide identification