5-Aryltetrazoles from Direct C-H Arylation with Aryl Bromides.
Yuan ZhangJack Chang Hung LeeMatthew R ReeseBrian P BoscoeJohn M HumphreyChristopher J HelalPublished in: The Journal of organic chemistry (2020)
A mild, direct C-H arylation of 1-substituted tetrazoles to 5-aryltetrazoles is developed using a Pd/Cu cocatalytic system with readily available aryl bromides. The methodology avoids late-stage usage of azides and tolerates a wide range of functionalities.
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