Blockade of TGF-β (Transforming Growth Factor Beta) Signaling by Deletion of Tgfbr2 in Smooth Muscle Cells of 11-Month-Old Mice Alters Aortic Structure and Causes Vasomotor Dysfunction-Brief Report.
Chloe Y LeeStoyan N AngelovJay ZhuLianxiang BiNicole SanfordIlkay Alp YildirimDavid A DichekPublished in: Arteriosclerosis, thrombosis, and vascular biology (2022)
Loss of TGF-β signaling in aortic SMC of 1-year-old mice does not cause early severe aortopathy or death; however, it causes mild structural and substantial physiological abnormalities. SMC TGF-β signaling plays an important role in maintaining aortic homeostasis in older mice. This role should be considered in the design of clinical studies that aim to prevent aortopathy by blocking SMC TGF-β signaling.
Keyphrases
- transforming growth factor
- aortic valve
- epithelial mesenchymal transition
- high fat diet induced
- left ventricular
- pulmonary artery
- physical activity
- oxidative stress
- heart failure
- aortic dissection
- metabolic syndrome
- coronary artery
- pulmonary hypertension
- atrial fibrillation
- middle aged
- pulmonary arterial hypertension