MYC status in HIV-associated plasmablastic lymphoma: dual-colour CISH, FISH and immunohistochemistry.

Sugeshnee PatherThembi MashelePascale WillemMoosa PatelYvonne PernerMantoa MotaungNatasha NagiahFaadil WajaVinitha PhilipAtul LakhaMartin J Hale

Published in: Histopathology (2021)

Majority of the HIV-associated PBL tumours harbour MYC aberrations. Due to the persistently inferior survival outcome of HIV-associated PBL in the era of antiviral treatment, targeted and/or intensified therapy of oncogenic MYC may need to be explored in future.

Keyphrases

antiretroviral therapy
hiv positive
hiv testing
hiv infected
human immunodeficiency virus
hepatitis c virus
hiv aids
transcription factor
men who have sex with men
south africa
stem cells
diffuse large b cell lymphoma
cancer therapy
current status
drug delivery
mesenchymal stem cells
copy number