Activation of Stimulator of IFN Genes (STING) Causes Proteinuria and Contributes to Glomerular Diseases.
Alla MitrofanovaAntonio FontanellaMatthew TolericoShamroop MallelaJudith Molina DavidYiqin ZuoMarcia BoulinaJin-Ju KimJavier SantosMengyuan GeAlexis SloanWadih IssaMargaret GurumaniJeffrey D PresslyMarie ItoMatthias KretzlerSean EddyRobert G NelsonSandra MerscherGeorge W BurkeAlessia FornoniPublished in: Journal of the American Society of Nephrology : JASN (2022)
The activation of the STING pathway acts as a mediator of disease progression in DKD and Alport syndrome. Targeting STING may offer a therapeutic option to treat glomerular diseases of metabolic and nonmetabolic origin or prevent their development, progression, or both.