Trigonelline and vildagliptin antidiabetic effect: improvement of insulin signalling pathway.

Amat-Alrazaq A AldakinahMuhammad Yusuf Al-ShorbagyDalaal M AbdallahHanan S El-Abhar

Published in: The Journal of pharmacy and pharmacology (2017)

The beneficial effect of TRG on insulin sensitivity and glucose/ lipid homeostasis is mediated by the enhancement of the insulin signaling and antioxidant property. Moreover, the positive impact of VLD on pT308-Akt is an integral part in insulin signaling, and hence its antidiabetic effect.

Keyphrases

type diabetes
glycemic control
oxidative stress
signaling pathway
cell proliferation
metabolic syndrome
adipose tissue
blood pressure
anti inflammatory