Three New Lanostanoids with Anti-HCV Effects from Abies nukiangensis.

Yong-Li LiZhuo-Ni XuJie LiShuang LiangMin-Jie XueJian-Jun WuXian-Wen Yang

Published in: Chemistry & biodiversity (2022)

Three new lanostane derivatives (1-3) and twelve known triterpenoids (4-15) were isolated from the twigs and leaves of Abies nukiangensis. The structures of the new compounds were elucidated mainly by detailed analysis of their NMR and HR-ESI-MS spectroscopic data. Evaluation of the anti-HCV effects of all isolates showed that 3 exhibited moderate effect with the EC 50 value of 11.09 μM.

Keyphrases

hepatitis c virus
ms ms
high resolution
human immunodeficiency virus
magnetic resonance
mass spectrometry
multiple sclerosis
molecular docking
electronic health record
big data
machine learning
solid state
essential oil
molecular dynamics simulations