Severe bleeding diatheses in an elderly patient with combined type autoantibody against factor XIII A subunit; novel approach to the diagnosis and classification of anti-factor XIII antibodies.
M KunN SzuberÉ KatonaK PénzesA BonnefoyB BécsiF ErdődiG E RivardLászló MuszbekPublished in: Haemophilia : the official journal of the World Federation of Hemophilia (2017)
The anti-FXIII-A autoantibody exerted a combined effect including inhibition of FXIIIa and acceleration of FXIII decay in the plasma. IC50 and binding constant determinations added important information to the characterization of the autoantibody.