Effects of B cell depletion by CD19-targeted CAR-T cells in a murine model of systemic sclerosis.

Jerome AvouacAnne CauvetCindy OrvainMorgane BoulchFrançoise TilottaLy TuRaphaël ThuilletMina OttavianiChristophe GuignabertPhilippe BoussoYannick Allanore

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2023)

B-cell therapies failed to show efficacy in the Fra2 transgenic mice. The exacerbated Fra-2 lung inflammatory burden stimulated accumulation and expansion of activated CD19-targeted CAR-T cells, secondarily inducing T-cell activation and systemic inflammation, finally leading to disease worsening.

Keyphrases

systemic sclerosis
interstitial lung disease
induced apoptosis
cancer therapy
cell cycle arrest
oxidative stress
endoplasmic reticulum stress
risk factors
drug delivery