Comprehensive genomic profiling from C-CAT database unveiled over 80% presence of oncogenic drivers in anaplastic thyroid carcinoma including BRAF, RAS family, NF1, and FGFR1.

Yuki SaitoHidenori KageKenya KobayashiTeru KamogashiraOsamu FukuokaKoji YamamuraSatoshi YamashitaMasahiko TanabeKatsutoshi OdaKenji Kondo

Published in: Clinical endocrinology (2024)

Comprehensive genomic analysis of ATC in Japan revealed distinct molecular subgroups, highlighting the importance of BRAF V600E mutations, particularly V600E, as potential therapeutic targets and suggest the relevance of tailor-made therapeutic strategies based on genomic profiling.

Keyphrases

single cell
copy number
wild type
signaling pathway
metastatic colorectal cancer
transcription factor
gene expression
emergency department
cell proliferation
risk assessment
dna methylation
inflammatory response
human health
climate change