Dolutegravir plus Two Different Prodrugs of Tenofovir to Treat HIV.
Willem Daniel Francois VenterMichelle A MoorhouseSimiso Mandisa SokhelaLee FairlieNonkululeko MashabaneMasebole MasenyaCelicia M SerenataGodspower AkpomiemieAmbar QaviNomathemba C ChandiwanaShane A NorrisMatthew Francis ChersichPolly ClaydenElaine J AbramsNatasha ArulappanAlinda G Vos-SedaKaitlyn McCannBryony SimmonsAndrew HillPublished in: The New England journal of medicine (2019)
Treatment with DTG combined with either of two tenofovir prodrugs (TAF and TDF) showed noninferior efficacy to treatment with the standard-care regimen. There was significantly more weight gain with the DTG-containing regimens, especially in combination with TAF, than with the standard-care regimen. (ADVANCE ClinicalTrials.gov number, NCT03122262.).