Differences in HIV-1 reservoir size, landscape characteristics and decay dynamics in acute and chronic treated HIV-1 Clade C infection.
Kavidha ReddyGuinevere Q LeeNicole ReddyTatenda J B ChikoworeKathy BaisleyKrista L DongBruce D WalkerXu G YuMathias D LichterfeldThumbi Ndung'uPublished in: medRxiv : the preprint server for health sciences (2024)
Overall, our results show that whereas ART initiated in hyperacute HIV-1 subtype C infection did not impact reservoir seeding, it was nevertheless associated with more rapid decay of intact viral genomes, decreased genetic complexity and immune escape in reservoirs, which could accelerate reservoir clearance when combined with other interventional strategies.
Keyphrases
- men who have sex with men
- hiv testing
- hiv positive
- antiretroviral therapy
- hiv infected
- water quality
- liver failure
- human immunodeficiency virus
- hiv aids
- drug induced
- hepatitis c virus
- intensive care unit
- single cell
- copy number
- genome wide
- south africa
- acute respiratory distress syndrome
- newly diagnosed
- aortic dissection
- mechanical ventilation