Identification of sequence polymorphisms in the mitochondrial deoxyribonucleic acid displacement-loop region as risk factors for systemic lupus erythematosus.

Ruixue Lai Xiaoyun Zhang Kuangyuan Qiao Xueqing Gao Shang Li Ruixing ZhangYixin QiChenxing Peng

Published in: Archives of rheumatology (2020)

This study indicated the SNPs in the mtDNA may associated with the risk of SLE. Analysis of SNPs in the mitochondrial D-loop may help identify individuals who are at high risk of developing SLE.

Keyphrases

systemic lupus erythematosus
disease activity
oxidative stress
genome wide
copy number
rheumatoid arthritis
mitochondrial dna
gene expression