The Effects of Mesenchymal Stem Cells Loaded with Oncolytic Coxsackievirus A21 on Mouse Models of Colorectal Cancer.

Reza KarbalaeeSaber MehdizadehHadi Esmaeili Gouvarchin GhalehMorteza IzadiBahman Jalali KondoriRuhollah DorostkarSeyed Morteza Hosseini

Published in: Current cancer drug targets (2024)

The results of the current study suggest that MSCs loaded with oncolytic CVA21 therapy for the CRC mouse model may have some potential advantages. On the other hand, the results of the study showed that, in addition to activating the acquired immune system, the use of MSCs loaded with oncolytic CVA21 also stimulates the innate immune system by increasing level of nitric oxide.

Keyphrases

mesenchymal stem cells
mouse model
nitric oxide
drug delivery
umbilical cord
immune response
wound healing
signaling pathway
bone marrow
risk assessment
climate change
hydrogen peroxide
nitric oxide synthase
human health