Downregulation of the histone methyltransferase SETD2 promotes imatinib resistance in chronic myeloid leukaemia cells.

Yaru ShengZhongzhong JiHuifang ZhaoJinming WangChaping ChengWeimin XuXue WangYuman HeKaiyuan LiuLi LiThibault VoeltzelVeronique Maguer-SattaWei-Qiang Gao Helen He Zhu

Published in: Cell proliferation (2019)

Our study not only emphasizes the regulatory mechanism of SETD2 in CML, but also provides promising therapeutic strategies for overcoming the imatinib resistance in patients with CML.

Keyphrases

chronic myeloid leukemia
induced apoptosis
signaling pathway
cell cycle arrest
cell proliferation
dna methylation
bone marrow
acute myeloid leukemia
transcription factor
dendritic cells
oxidative stress
immune response
gene expression
drug induced