Unraveling the Significance of DGCR8 and miRNAs in Thyroid Carcinoma.
Lia RodriguesArnaud Da Cruz PaulaPaula SoaresJoão VinagrePublished in: Cells (2024)
MicroRNAs (miRNAs) act as negative regulators for protein-coding gene expression impacting cell proliferation, differentiation, and survival. These miRNAs are frequently dysregulated in cancer and constitute classes of blood-based biomarkers useful for cancer detection and prognosis definition. In thyroid cancer (TC), the miRNA biogenesis pathway plays a pivotal role in thyroid gland formation, ensuring proper follicle development and hormone production. Several alterations in the miRNA biogenesis genes are reported as a causality for miRNA dysregulation. Mutations in microprocessor component genes are linked to an increased risk of developing TC; in particular, a recurrent mutation affecting DGCR8 , the E518K. In this review, we explore these novel findings and resume the current state-of-the-art in miRNAs in thyroid carcinomas.
Keyphrases
- gene expression
- papillary thyroid
- cell proliferation
- squamous cell
- genome wide
- dna methylation
- genome wide identification
- transcription factor
- lymph node metastasis
- emergency department
- bioinformatics analysis
- small molecule
- childhood cancer
- free survival
- protein protein
- electronic health record
- adverse drug
- loop mediated isothermal amplification