Is methotrexate safe for men with an immune-mediated inflammatory disease and an active desire to become a father? Results of a prospective cohort study (iFAME-MTX).
Luis Fernando Perez-GarciaEsther RöderBouwe P KrijtheLaura Jc Kranenburg-van KoppenRoxanne van AdrichemEls ZirkzeePieter H GriffioenKris PeetersMarry LinEduard A StruysGerrit JansenMartijn Ba van DoornRobert de JongeGert R DohleRadboud Jem DolhainPublished in: Annals of the rheumatic diseases (2023)
Treatment with MTX is not associated with testicular toxicity, consistent with the very low concentration of intracellular MTX-PG. Therefore, therapy with MTX can be safely started or continued in men and with a wish to become a father.