Identification of the distribution of human endogenous retroviruses K (HML-2) by PCR-based target enrichment sequencing.

Bei XueTiansheng ZengDavid J KelvinDongsheng YangStanley L LinLeonardo A SechiDavid J Kelvin

Published in: Retrovirology (2020)

Interestingly, PTESHK provides an approach for the identification of the genome-wide distribution of HERV-K (HML-2) and can be used for the identification of polymorphic loci. Since polymorphic HERV-K (HML-2) integrations are suspected to be related to various diseases, PTESHK can supplement other emerging techniques in accessing polymorphic HERV-K (HML-2) elements in cancer and autoimmune diseases.

Keyphrases

genome wide
bioinformatics analysis
endothelial cells
dna methylation
papillary thyroid
pulmonary embolism
single cell
gene expression
young adults
copy number