Macrophages reprogramming driven by cancer-associated fibroblasts under FOLFIRINOX treatment correlates with shorter survival in pancreatic cancer.

Zainab HussainThomas BertranPascal FinettiEugenie LohmannEmilie MamessierGhislain BidautFrançois BertucciMoacyr RegoRichard Tomasini

Published in: Cell communication and signaling : CCS (2024)

Our study provides insight into the complex interactions between TME cells under FOLFIRINOX treatment. It suggests potential novel candidates that could be used as therapeutic targets in combination with FOLFIRINOX to prevent and alleviate TME influx on therapeutic resistance as well as biomarkers to predict FOLFIRINOX response in PDAC patients. Video Abstract.

Keyphrases

locally advanced
newly diagnosed
ejection fraction
induced apoptosis
rectal cancer
prognostic factors
radiation therapy
combination therapy
chronic kidney disease
cell cycle arrest
patient reported outcomes
endoplasmic reticulum stress
human health