Login / Signup

The utility of ETV1, ETV4 and ETV5 RNA in-situ hybridization in the diagnosis of CIC-DUX sarcomas.

Steven Christopher SmithNallasivam PalanisamyElizabeth MartinJorge AlmenaraJonathan B McHughEun-Young K ChoiDavid R LucasBryan L BetzDafydd ThomasRajiv M Patel
Published in: Histopathology (2016)
We identified overexpression of ETV1, ETV4 and ETV5 transcripts in situ in CIC-DUX4 sarcomas using a robust assay in routine archival sections. One previously unclassified round cell sarcoma showed ETV1/4/5 positivity, and was proved to harbour a CIC rearrangement by break-apart FISH. The sensitivity and specificity observed with our in-situ hybridization assay implies potential utility as an ancillary diagnostic technique, particularly when faced with limited biopsy samples.
Keyphrases
  • acute lymphoblastic leukemia
  • high grade
  • stem cells
  • risk assessment
  • climate change
  • mesenchymal stem cells