Preparation, Purification and Performance Evaluation of Polyclonal Antibody Against SARS-CoV-2 Produced in Rat.

Fatemeh Yaghoobizadeh Mohammad Roayaei Ardakani Mohammad Mehdi Ranjbar Mohammad Khosravi Hamid Galehdari

Published in: Advanced pharmaceutical bulletin (2022)

Herein, we presented a simple and cheap method for the purification of whole viral particles with relatively high quality. The results verified that these antigens could elicit a good immune response in the rat. The obtained pAbs showed a good specificity toward SARS-CoV-2 antigens. Accordingly, this study proposes a promising method for viral vaccine development.

Keyphrases

sars cov
immune response
respiratory syndrome coronavirus
dendritic cells
oxidative stress
toll like receptor
molecularly imprinted