Effects of Porphyromonas gingivalis and Fusobacterium nucleatum on inflammasomes and their regulators in H400 cells.

Kübra AralMichael R MilwardDhanak GuptaPaul R Cooper

Published in: Molecular oral microbiology (2020)

Pg alone increased IL-1β by upregulating AIM2, NLRP3 and downregulating POP1. Fn promoted IL-1β by increasing AIM2 and downregulating POP1. Pg + ATP with or without Fn upregulated NLRP3, IL-1β by downregulating POP1. Periodontal pathogens may contribute to HNSCC pathogenesis by increasing the IL-1β response due to inflammasome dysregulation.

Keyphrases

induced apoptosis
oxidative stress
cell death
cell proliferation
signaling pathway
pi k akt