Triple knockdown of CDC37, HSP90-alpha and HSP90-beta diminishes extracellular vesicles-driven malignancy events and macrophage M2 polarization in oral cancer.

Kisho OnoChiharu SogawaHotaka KawaiManh Tien TranEman A TahaYanyin LuMay Wathone OoYuka OkushaHirohiko OkamuraSoichiro IbaragiMasaharu TakigawaKen-Ichi KozakiHitoshi NagatsukaAkira SasakiKuniaki OkamotoStuart K CalderwoodTakanori Eguchi

Published in: Journal of extracellular vesicles (2020)

CDC37: cell division control 37; EMT: epithelial-mesenchymal transmission; EV: extracellular vesicles; HNSCC: head and neck squamous cell carcinoma; HSP90: heat shock protein 90; TAM: tumour-associated macrophage.

Keyphrases

heat shock protein
heat shock
adipose tissue
cell cycle
epithelial mesenchymal transition
bone marrow
cell therapy
cell proliferation
mesenchymal stem cells