Comparative safety of adding serotonin and norepinephrine reuptake inhibitors (SNRIs) versus nonsteroidal anti-inflammatory drugs (NSAIDs) to short-acting opioids for non-malignant pain in nursing homes.
Shao-Hsien LiuYiyang YuanJonggyu BaekAnthony P NunesJayne PawasauskasAnne L HumeKate L LapanePublished in: Journal of the American Geriatrics Society (2023)
Among nursing home residents, adding SNRIs to short-acting opioids does not appear to increase risk of delirium relative to initiating NSAIDs. Understanding the comparative safety of pain regimens is needed to inform clinical decisions in a medically complex population often excluded from clinical research.