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Association of CSF GAP-43 With the Rate of Cognitive Decline and Progression to Dementia in Amyloid-Positive Individuals.

Annika ÖhrfeltAndréa L BenedetNicholas James AshtonHlin KvartsbergManu VandijckMichael W WeinerJohn Q TrojanowskiLeslie M ShawHenrik ZetterbergKaj Blennow
Published in: Neurology (2022)
and Classification of Evidence: This study provides Class III classification of evidence that high baseline levels of CSF GAP-43 are associated to progression in Aβ-positive individuals, with a more aggressive neurodegenerative process, faster rate of cognitive decline and increased risk of converting to dementia.
Keyphrases
  • cognitive decline
  • mild cognitive impairment
  • machine learning
  • deep learning
  • cognitive impairment
  • cerebrospinal fluid