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When E-cadherin is away, centrosomes can play.

Diana Vargas-HurtadoRenata Basto
Published in: The Journal of cell biology (2017)
Centrosome clustering is a process frequently used by cancer cells with extra centrosomes to avoid multipolar divisions. How cell-intrinsic properties influence clustering is not entirely known. In this issue, Rhys et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201704102) report an unexpected link between clustering capacity and cortical contractility through E-cadherin and DDR1 proteins.
Keyphrases
  • single cell
  • rna seq
  • cell therapy
  • stem cells
  • bone marrow