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Silver-catalyzed monofluoroalkylation of heteroarenes with α-fluorocarboxylic acids: an insight into the solvent effect.

Chunfang GuoZhaolong LiuXiangye LiXuliang HanYueyun LiHui LiuLizhi ZhangXinjin LiYunhui Dong
Published in: Chemical communications (Cambridge, England) (2022)
A mild and efficient method for direct C-H monofluoroalkylation of heteroarenes with easily accessible and inexpensive α-fluorocarboxylic acids has been developed. This silver-catalyzed reaction affords mono- and bis-monofluoroalkylated heteroarenes in good yields under mild conditions, and the solvent effect on the monofluoroalkylation reaction is discussed in detail.
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