An epigenome-wide study of obesity in African American youth and young adults: novel findings, replication in neutrophils, and relationship with gene expression.
Xiaoling WangYue PanHaidong ZhuGuang HaoYisong HuangVernon BarnesHuidong ShiHarold SniederJames PankowKari NorthMegan GroveWeihua GuanEllen DemerathYanbin DongShaoyong SuPublished in: Clinical epigenetics (2018)
In this study of youth and young adults, we identified 29 novel CpG sites associated with obesity and replicated the majority of the CpG sites previously identified. We further demonstrated that the majority of the obesity-related CpG sites in leukocytes were not driven by cell composition or obesity-related cardio-metabolic risk factors. We also provided the direct link between DNA methylation-gene expression-obesity for 5 genes.
Keyphrases
- dna methylation
- gene expression
- young adults
- insulin resistance
- metabolic syndrome
- weight loss
- genome wide
- high fat diet induced
- type diabetes
- weight gain
- african american
- risk factors
- physical activity
- mental health
- adipose tissue
- skeletal muscle
- body mass index
- single cell
- mesenchymal stem cells
- transcription factor