Severe dysbiosis and specific Haemophilus and Neisseria signatures as hallmarks of the oropharyngeal microbiome in critically ill COVID-19 patients.
Juliana de CastilhosEli ZamirTheresa HippchenRoman RohrbachSabine SchmidtSilvana HenglerHanna SchumacherMelanie NeubauerSabrina KunzTonia Müller-EschAndreas HiergeistAndré GessnerDina KhalidRogier GaiserNyssa CullinStamatia M PapagiannarouBettina Beuthien-BaumannAlwin KrämerRalf BartenschlagerDirk JägerMichael MüllerFelix HerthDaniel DuerschmiedJochen SchneiderRoland M SchmidJohann F EberhardtYascha KhodamoradiMaria J G T VehreschildAndreas TeufelMatthias P EbertPeter HauBernd SalzbergerPaul SchnitzlerHendrik PoeckEran ElinavUta MerleChristoph K Stein-ThoeringerPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)
In addition to the infection per se, several factors shape the oropharyngeal microbiome of severely affected COVID-19 patients and deserve consideration in the interpretation of the role of the microbiome in severe COVID-19. Nevertheless, we were able to extract microbial features that can help to predict clinical outcomes.