Comparative transcriptome analysis of sinonasal inverted papilloma and associated squamous cell carcinoma: Out-HOXing developmental genes.
Diana BellAchim H BellMichael E KupfermanVictor G PrietoRandal S WeberEhab Y HannaPublished in: Head & neck (2019)
We conclude that sinonasal carcinomas arising from papillomas are mainly defined by overexpressed developmental/homeobox genes, which provide the potential for transformation/plasticity, along with differentiation and proliferation behavior of neoplastic cells. Our results support HOXA9 and CA9 as biomarkers for carcinomas, with CA9 emerging as a predictive marker of recurrence.
Keyphrases
- squamous cell carcinoma
- induced apoptosis
- genome wide
- high grade
- bioinformatics analysis
- genome wide identification
- signaling pathway
- cell cycle arrest
- protein kinase
- long non coding rna
- genome wide analysis
- dna methylation
- long noncoding rna
- chronic rhinosinusitis
- lymph node metastasis
- human health
- free survival
- cell death
- radiation therapy
- climate change
- cell proliferation