Ultrasmall FeS2 Nanoparticles-Decorated Carbon Spheres with Laser-Mediated Ferrous Ion Release for Antibacterial Therapy.
Juqun XiLanfang AnYaling HuangJian JiangYanqiu WangGen WeiZhilong XuLei FanLizeng GaoPublished in: Small (Weinheim an der Bergstrasse, Germany) (2021)
Recent progress in nanotechnology and the ancient use of sulfur in treating dermatological disorders have promoted the development of nano-sulfides for antimicrobial applications. However, the variable valences and abundant forms of nano-sulfides have complicated investigations on their antibacterial activity. Here, carbon nanospheres (CNSs) with decoration of ultrasmall FeS2 nanoparticles (CNSs@FeS2 ) is synthesized, and their antibacterial ability and mechanism are explored. The CNSs@FeS2 released Fe2+ and sulfur ions simultaneously through dissolution and disproportionation. In vitro study indicated that the released Fe2+ killed bacteria by increasing the oxidative state of bacterial surfaces and intracellular molecules. Importantly, the released sulfur exhibited a protective effect on Fe2+ , ensuring the stable existence of Fe2+ to continuously combat bacteria. Moreover, the carbon shells of CNSs@FeS2 not only prevented the aggregation of FeS2 but also accelerated the release of Fe2+ through photothermal effects to achieve synergistic hyperthermia/Fe2+ therapy. In vivo experiments indicated that treatment with CNSs@FeS2 resulted in a marked reduction in bacterial number and improvement in survival in an acute peritonitis mouse model, and antibacterial wound experiments demonstrated high efficacy of CNSs@FeS2 -enabled synergistic hyperthermia/Fe2+ therapy. Thus, this study clarifies the antibacterial mechanism of FeS2 and offers a synergetic therapeutic platform with laser-mediated Fe2+ release for antibacterial applications.
Keyphrases
- silver nanoparticles
- metal organic framework
- aqueous solution
- mouse model
- visible light
- staphylococcus aureus
- essential oil
- anti inflammatory
- intensive care unit
- escherichia coli
- stem cells
- high speed
- high resolution
- reactive oxygen species
- high throughput
- quantum dots
- biofilm formation
- cystic fibrosis
- hepatitis b virus
- highly efficient
- combination therapy
- extracorporeal membrane oxygenation
- replacement therapy
- smoking cessation
- respiratory failure
- drug release
- water soluble
- reduced graphene oxide
- oxide nanoparticles