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Epigenetic scores derived in saliva are associated with gestational age at birth.

Katie MckinnonEleanor L S ConoleKadi VaherRobert F HillaryDanni A GaddJustyna BinkowskaGemma SullivanAnna J StevensonAmy CorriganLee MurphyHeather C WhalleyHilary RichardsonRiccardo E MarioniSimon R CoxJames P Boardman
Published in: Clinical epigenetics (2024)
Low birth GA is substantially associated with a set of EpiScores. The set was enriched for inflammatory proteins, providing new insights into immune dysregulation in preterm infants. SES had fewer associations with EpiScores; these tended to have small effect sizes and were not statistically significant after adjusting for inflammatory comorbidities. This suggests that inflammation is unlikely to be the primary axis through which SES becomes embedded in the development of preterm infants in the neonatal period.
Keyphrases
  • gestational age
  • preterm infants
  • birth weight
  • oxidative stress
  • low birth weight
  • preterm birth
  • pet ct
  • dna methylation
  • gene expression
  • physical activity