Dendritic Cell Plasticity, Radiation, and Newton's Third Law.
Pawel KalinskiShipra GandhiKathleen M KokolusPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Regulatory T (Treg) cells protect damaged tissues but can undermine the effects of cancer treatments, including radiation (RTx). Intratumoral immuno-stimulatory dendritic cells (cDC1) respond to RTx with production of Treg-attracting MDC/CCL22, undermining RT effects. That effect can be reversed by EGFR-targeted IFNa, highlighting cDC1 plasticity and relevance as therapeutic targets.
Keyphrases
- dendritic cells
- induced apoptosis
- immune response
- regulatory t cells
- papillary thyroid
- small cell lung cancer
- cell cycle
- cell cycle arrest
- gene expression
- epidermal growth factor receptor
- squamous cell
- radiation induced
- transcription factor
- tyrosine kinase
- cancer therapy
- liver injury
- squamous cell carcinoma
- cell death
- endoplasmic reticulum stress
- signaling pathway
- young adults
- drug delivery
- oxidative stress
- pi k akt
- cell proliferation