Drug targeting of aminoacyl-tRNA synthetases in Anopheles species and Aedes aegypti that cause malaria and dengue.

Soumyananda ChakrabortiJyoti Chhibber-GoelAmit Sharma

Published in: Parasites & vectors (2021)

Structural analysis of two important aminoacyl-tRNA synthetases [prolyl (PRS) and phenylanalyl (FRS)] of Anopheles spp. suggests structural and sequence similarity with potential antimalarial inhibitor [halofuginone (HF) and bicyclic azetidine (BRD1369)] binding sites. This suggests the potential for repurposing of these inhibitors against the studied Anopheles spp. and Ae. aegypti.

Keyphrases

aedes aegypti
zika virus
dengue virus
plasmodium falciparum
human health
cancer therapy
heart failure
risk assessment
climate change
adverse drug
amino acid
atrial fibrillation
acute heart failure
genetic diversity