Development of Cross-Reactive Live Attenuated Influenza Vaccine Candidates against Both Lineages of Influenza B Virus.

Pei-Fong WongIrina Isakova-SivakEkaterina StepanovaElena KrutikovaEkaterina A BazhenovaAndrey RekstinLarisa Rudenko

Published in: Vaccines (2024)

The new RG system for B60 MDV allowed the rapid generation of type B LAIV reassortants with desired genome compositions. The generation of hybrid LAIV reassortants with HA and NA genes belonging to the opposite IBV lineages is a promising approach for the development of IBV vaccines with broad cross-protection.

Keyphrases

genome wide
gene expression
transcription factor
genome wide identification
bioinformatics analysis