PET/MR imaging of inflammation in atherosclerosis.
Max L SendersClaudia CalcagnoAhmed TawakolMatthias NahrendorfWillem J M MulderZahi Adel FayadPublished in: Nature biomedical engineering (2022)
Myocardial infarction, stroke, mental disorders, neurodegenerative processes, autoimmune diseases, cancer and the human immunodeficiency virus impact the haematopoietic system, which through immunity and inflammation may aggravate pre-existing atherosclerosis. The interplay between the haematopoietic system and its modulation of atherosclerosis has been studied by imaging the cardiovascular system and the activation of haematopoietic organs via scanners integrating positron emission tomography and resonance imaging (PET/MRI). In this Perspective, we review the applicability of integrated whole-body PET/MRI for the study of immune-mediated phenomena associated with haematopoietic activity and cardiovascular disease, and discuss the translational opportunities and challenges of the technology.
Keyphrases
- positron emission tomography
- cardiovascular disease
- computed tomography
- human immunodeficiency virus
- contrast enhanced
- pet ct
- pet imaging
- magnetic resonance imaging
- high resolution
- oxidative stress
- hepatitis c virus
- antiretroviral therapy
- heart failure
- atrial fibrillation
- diffusion weighted imaging
- hiv infected
- type diabetes
- cardiovascular events
- magnetic resonance
- papillary thyroid
- squamous cell
- metabolic syndrome
- hiv positive
- energy transfer
- photodynamic therapy
- quantum dots
- subarachnoid hemorrhage