Pro-inflammatory mediators released by activated monocytes promote aortic valve fibrocalcific activity.
Peijian ZhangErlinda TheZichao LuoYufeng ZhaiQingzhou YaoLihua AoDavid A FullertonDingli XuXianzhong MengPublished in: Molecular medicine (Cambridge, Mass.) (2022)
This study demonstrates that activated monocytes elevate the fibrogenic and osteogenic activities in human AVICs through a paracrine mechanism. TNF-α and RANTES mediate the pro-fibrogenic effect of activated monocytes on AVICs through activation of JNK, and TNF-α also activates NF-κB to elevate AVIC osteogenic activity. The results suggest that infiltrated monocytes elevate AVIC fibrocalcific activity to promote CAVD progression.
Keyphrases
- aortic valve
- dendritic cells
- peripheral blood
- mesenchymal stem cells
- rheumatoid arthritis
- signaling pathway
- bone marrow
- transcatheter aortic valve replacement
- endothelial cells
- transcatheter aortic valve implantation
- aortic valve replacement
- cell death
- oxidative stress
- heart failure
- cell proliferation
- pi k akt
- left ventricular
- inflammatory response
- toll like receptor