IL-15 superagonist RLI has potent immunostimulatory properties on NK cells: implications for antimetastatic treatment.

Mélanie DesboisCoralie BéalMélinda CharrierBenjamin BesseGuillaume MeuriceNicolas CagnardYannick JacquesDavid BéchardLydie CassardNathalie Chaput

Published in: Journal for immunotherapy of cancer (2021)

Collectively, our work demonstrates superior activity of RLI compared with rhIL-15 in modulating and activating NK cells and provides additional evidences for a therapeutic strategy using RLI as antimetastatic molecule.

Keyphrases

nk cells
signaling pathway
anti inflammatory
replacement therapy