Structural Changes in the Medial Prefrontal Cortex and Anterior Cingulate Cortex of Dehydroepiandrosterone-Induced Wistar Rat Model of Polycystic Ovarian Syndrome.

Joseph Igbo Enya Victor Okoliko Ukwenya Aminu Imam Aisha Kopada Samson Olorunnado Oluwole B Akinola

Published in: Basic and clinical neuroscience (2022)

DHEA-induced PCOS results in anxiety and depressive behavior with structural alteration in rats, possibly through the elevation of MDA, ROS, and IL-6 levels, which also attributes to impaired emotional and executive functions in the mPFC and ACC.

Keyphrases

prefrontal cortex
high glucose
diabetic rats
functional connectivity
cell death
bipolar disorder
drug induced
metabolic syndrome
oxidative stress
depressive symptoms
skeletal muscle
stress induced
sleep quality
cell proliferation
insulin resistance
pi k akt
cell cycle arrest