Anti-mycobacterial natural products and mechanisms of action.
Jianying HanXueting LiuLixin ZhangRonald J QuinnYunjiang FengPublished in: Natural product reports (2021)
Covering: up to June, 2020Tuberculosis (TB) continues to be a major disease with high mortality and morbidity globally. Drug resistance and long duration of treatment make antituberculosis drug discovery more challenging. In this review, we summarize recent advances on anti-TB natural products (NPs) and their potential molecular targets in cell wall synthesis, protein production, energy generation, nucleic acid synthesis and other emerging areas. We highlight compounds with activity against drug-resistant TB, and reveal several novel targets including Mtb biotin synthase, ATP synthase, 1,4-dihydroxy-2-naphthoate prenyltransferase and biofilms. These anti-TB NPs and their targets could facilitate target-based screening and accelerate TB drug discovery.
Keyphrases
- mycobacterium tuberculosis
- drug discovery
- drug resistant
- pulmonary tuberculosis
- nucleic acid
- cell wall
- multidrug resistant
- acinetobacter baumannii
- type diabetes
- cardiovascular events
- risk factors
- small molecule
- genome wide
- cardiovascular disease
- binding protein
- antiretroviral therapy
- hiv infected
- human health
- oxide nanoparticles